Background: Nowadays, different clinical behaviors of odontogenic cysts, little information about their biological agents, importance of diagnosis, and early diagnosis of these lesions have encouraged the researchers to conduct new studies. Therefore, the study's objectives were to measure alpha tocopherol levels in patients with OKC and compare them to alpha tocopherol levels in serum of healthy, normal individuals Methods: Twelve randomly chosen healthy people made up Group A, the control group, while 12 patients with an OKC diagnosis that had been histopathologically verified made up Group B. The amount of alpha tocopherol was measured in "mg/mL" units. Results: When compared to healthy controls (mean ± SD = 12.075 ± 1.6504 mg/mL), the mean vitamin E level was found to be lower (mean ± SD = 5.417 ±1.9244 mg/mL). Conclusion: OKC patients had lower amounts of vitamin E than normal, healthy people. It can definitely aid in predicting more invasive tendencies of pathologic lesions like OKC.