Abstract "Green sustainable chemistry" uses chemical technology to make less harmful things and procedures for our planet's ecosystems (GSC). Green chemistry uses eco-friendly, highefficiency synthetic techniques to make life-saving drugs. This decreases medication development's environmental effect and speeds guide optimization. HPAs have various economic and environmental benefits as catalysts. The large range of reaction domains in which heteropolyacid catalysts can be utilised as acids is examined. SPNPs are an efficient, cost-effective, and eco-friendly catalyst (H14[NaP5W30O110]/SiO2). This method has high yields, easy operation, and an uncomplicated product-working procedure. SPNPs (H14[NaP5W30O110]/SiO2) offer hydrolytic and thermal stability. Preyssler's anion is nontoxic and reusable.