Abstract Background:In 2017, East Java Province was ranked second in Indonesia to discover tuberculosis (TB) patients. The Southern Regional Health Center of Kediri City was ranked fifth out of 27 cases. Objectives of the study: This study aims to analyze the problem and prioritize health issues of TB in the Southern Regional Health Center of Kediri in 2019. Methods: The observation was carried out using performance assessment for the Southern Regional Health Center data in 2018 with the ultrasound and fishbone methods. Results: It was noticed that all TB cases were found and treated, including the discovery of suspected TB cases and the successful treatment of all TB cases (Success Rate/SR). The main problems in the Southern Regional Health Center in 2019 were that the suspected tuberculosis sputum pot was not returned, the people’s lack of knowledge, and less active TB cadres. Conclusion: Some of the problems found are the lack of knowledge regarding TB, less active TB cadres, lack of coordination among TB cadres, limitation of people who are willing to become TB cadres, and the time limitation of TB cadres.