ABSTRACT: Diabetes mellitus and thyroid gland abnormalities are interlinked and coexist with influencing each other. Current study was planned and conducted to evaluate thyroid status in patients with type-2 diabetics. The main aim of the study was to understand the relationship between diabetes mellitus and thyroid abnormalities. Total 100 known diabetic patients were studied, out of them 37 were males with the mean age 59.81 ± 12.8 years, and 63 females with average age of 55.31 ±11.10 years. 50 non-diabetic healthy subjects included 13 males and 37 female of mean age 48.86 ± 12.9 and 48.86 ± 17.94 years respectively selected as a control. All the patients were evaluated for thyroid profile (TSH, FT3, and FT4) and diabetic profile (RBS and HbA1c) by using Cobas C-311 and Cobas E411 fully automated immunoassay analyzer. The observations were recorded. The result showed that, out of 100 diabetic subjects 41.03% male and 58.97% female were faced with euthyroid and the remaining 22% had thyroid dysfunctions. Hypothyroidism was more common in females (78.97%) as compared to men (21.05%). The mean values for TSH, FT3 and FT4 at (p> 0.05%) probability level shows statistically no significant difference. The relationship between diabetes and thyroid abnormalities was significantly difference, interdependency of these two conditions and evaluation of thyroid hormones status with the diabetic profile in the early days of diabetes is recommended. This will induce the management strategies of diabetes and can delay and avoid the progression of the secondary complications in diabetic patients with uncontrolled diabetes.