The purpose of this study was to compare the clinical features of type 2 diabetes patients with and without cardiovascular disease and stroke to those of similarly aged healthy controls. newline For this study, we used biochemical markers such as newline and LPL PvuII, as well as the MTHFR C677T gene polymorphism, to analyse blood and urine samples. The risk of cardiovascular disease and stroke appears to be elevated in T2DM newline patients due to elevated levels of HbA1c, newlines, homocysteine malondialdehyde, microalbuminuria, and lowered eGFR newline levels. Furthermore, the findings suggested that inflammation may have a role in the onset of CVD/stroke in diabetes patients. Risk assessment for diabetes complications requires the evaluation of biochemical markers in T2DM patients. Patients with T2DM may experience an increase in the prevalence of cardiovascular disease and new-onset stroke as a result of the global rise in the incidence of newonset T2DM. newline Monitoring biochemical indicators in the blood and urine on a regular basis may be an important newline step in helping newline diabetic patients avoid or delay the development of cardiovascular disease. A lack of correlation between LPL PvuII and MTHFR newlineC677T gene polymorphism data and biochemical markers in T2DM newline patients may have resulted from the study's small sample size. It's possible that conclusive evidence won't be available until until large, randomised clinical studies of newer treatments are conducted