Background:There are various routes in drug delivery system including intra-venous, intra-muscular, oral, sublingual etc. In all these routes time of action of drug, life of the drug differs. In oral route the drug is absorbed into circulation then it is metabolised in liver and then only the action of drug begins. As in transdermal patches the action of the drug is slow but has a long life i.e.., the effect of drug in the body is long compared to other routes. Dental pain is very common in orthodontic treatment due to the movement of the tooth and the pressure exerted by the orthodontic system. So this study will involve in evaluation of pain relief in patients taking tablets verses patients who are not taking tablets verses patients using transdermal patch undergoing orthodontic treatment Aim: To analyse the analgesic effect of transdermal patch in patients who are undergoing orthodontic treatment Materials and methods: 20 selected randomly after the placement of initial niti wire in mild crowding .1-4mm little irregularity index without extraction of teeth were selected for the study. Among that 10 were given trans- dermal patch (NUPATCH-DICLOFENAC SODIUM) and other 10 were not given trans-dermal patch. Pain intensity was noted using pain chart which was given to the patient and collected after 2 days. Pain was noted in time interval of 1hour, 4 hour, 1 day and 2 day. All the data were collected, which was computed and Statistics was done Results : All the data were statistically analyzed using spss software and the mean were analysed. It is found that that the analgesic dermatological patch has a good action in reducing dental pain , due to its long half life period and less systemic toxicity. Conclusion : Use of transdermal patch has a significant analgesic effect. This study reveals that transdermal patch had a significant analgesic effect and can also be used in routine dental practice.