Abstract: The therapy of COVID-19 has attracted great interest in Chloroquine. The latest focus on these chloroquine applications has contributed to a survey on the effect and possibility of hormonobiphase dose reaction on extremely biologically different models. The examination showed that chloroquin usually induced hormetal effects that impacted many types of cells, including tumour cell lines (e.g. human breasts, colons, colones) and nontumor cell lines, improved viral reproduction, motility of semen, varied behavioural endpoints, and decreased the risk of convulsions. These diverse and nuanced findings indicate that hormetic dose reactions with different biological models and endpoints are common in chloroquine treatments. These findings impact the nature of the study, including dosage number and distance, and suggest a variety of clinical challenges and opportunities focused on the expected outcome.