Abstract : Tulsi ( Ocimum sanctum) member of family ( Lamiaceae) is the most significant medicinal plants mentioned in Ayurvedic creative writing for its medicinal and religious properties. The root, seeds, and leaves are majorly used due to its therapeutically properties. Tulsi, beside with other health profit is known to have antibiotic properties. Hence, “antiviral activity” of aqueous/ ethanol/ methanol and chloroform extract of powdered drugs was investigated against reasonably important viruses of “veterinary importance”, Single stranded RNA virus. As per Ayurvedic literatures tulsi is mentioned under Helminthiasis because it is an anti-microbial agent. The uses of this plant on a daily basis are a witness to Ayurvedic intelligence and provide an pattern of earliest information contribution solutions to present trouble. It have also be exposed to respond to metabolic-stress by homogenize of blood sugar, blood pressure, Cholesterol, and mental state through encouraging result on remembrance and perception act and by its anxio-lytic and edronax effect. This drug is a famous for house hold medication for many diseases such as injury, respiratory disorders, hepatic disease, viral infection, earache, back pain, hiccup, inflammation of the conjunctiva in newborns, stomach diseases, urinary disorders, seborrhea disease, a variety of toxicity and mental stress. In the present studies literature review is mentioned along with its Morphology, Phytochemistry, Pharmacognoctiscal studies and various pharmacological activities and mainly anti-viral activity.