Endosulfan- one of the popular organochlorine insecticides was launched into the agricultural sector in the 1950s as a part of Green Revolution. Endosulfan was relatively inexpensive but offered high efficacy and stability that led to its extensive use as an agricultural pesticide in the global market for more than 30 years despite being labelled as a restricted Organochlorines (OC)-class agent. However, several cases of endosulfan poisonings started emerging periodically from many parts of the world. The most infamous chapter of endosulfan disaster is arguably the one that happened in Kerala- India over a span of 25 years. The aim of this article is to provide an in-depth overview of the tragic event and its outcomes, that contributed to a global ban recommendation of the dangerous pesticide.