Quantitative research necessitates an awareness of the actual or average amount of substances present in the sample and makes use of two methods of analysis based on the composition of the material present in the sample. These methods are known as traditional chemical analysis and instrumental analysis, respectively. Quantitative research needs one to be aware of the real or average quantity of chemicals that are present in the sample. In this article, we take a look at the many analytical techniques that have been published for the estimation of flupirtine, fluindione, mizolastine, and dapoxetine in bulk as well as in their particular dosage forms. This study also covers the methods for impurity profiling. It was found that very little work has been done on the chosen medications, and very few techniques have been described for the estimate of pharmaceuticals in bulk and their formulations. This is a problem since there is a great need for this information. There have been no methodologies that have been published on the chosen pharmaceuticals for the purpose of estimating contaminants linked to their synthetic pathway or packaging-related issues. As a result, we have chosen the medications listed above in order to create methodologies for estimating the impurities associated with these drugs