Etomidate has been widely used in western countries has now become available in India. Etomidate is preferred in patients with CAD, especially with poor left ventricular (LV) function as it provides stable cardiovascular profile but it has less inhibitory effect on pharyngolaryngeal reflex thus may cause less blunting of response to laryngoscopy and intubation. After getting approval from institutional ethics committee, study was carried out in all patients fulfilling the inclusion and exclusion criteria during the study period. Patient diagnosed or known case of CAD either from history, investigations were included in the study after obtaining written valid informed consent. There was no hypertension or hypotension in group A (EF<45%) but in group B (EF>45%) hypertension was noted in just 1 patient and no hypotension noted. Statistically they were non-significant (p value-0.077). There was no occurrence any arrhythmias or significant ST changes in either group at any point of time from induction to 10min after intubation.