ABSTRACT Background: Raising cardiovascular diseases and its associated comorbidity, health risks and consequences carry a massive health care system and economic burden on the society. Aim: To compare the different Indian manufactured drug eluting stents (DES) in patients undergoing primary percutaneous coronary intervention (PCI) with primary objective of major adverse cardiac and cerebrovascular events (MACCE). Study design: Observational, retrospective, and prospective study. Methodology: Study conducted at Sunshine Heart Institute from Jan 2016 to April 2018 in all the patients who have undergone primary PCI with Indian manufactured DES. The baseline clinical, procedural, in-hospital data and follow-up data was taken at 01, 03, 06 and 12 months, till end of study period at regular intervals, after the index procedure. Results: 163 patients were considered for the data analysis in 3 groups i.e. Premier (51), Tetrilimus (47) & YCF (65). Conclusion: All the three study groups have shown similar primary and secondary outcomes. However, further studies are required on large scale for accurate assessment and evaluation.