Abstract : Vaccines are very crucial for treating preventable diseases, but its need a constant environment like maintenance of temperature. Currently it is a barrier in healthcare scenario. In this paper, work is focused on the designing of the cold box which is capable to maintain a temperature range from 20 -8 0 C constantly using Peltier-based thermoelectric chip, specific structural design obtain through calculation and IoT based solutions. Another crucial characteristic of this instrument is that it delivers an optimal power usage forecast to keep the ideal vaccine storage in precise temperature range in presence of limited power supply from environment. Due to a collective action of the phase change material and thermoelectric device, the temperature inside the box is will be maintained. The details of the location and the temperature settings will be accessible and visible on the Blink Application. This box is an efficient carrier as it will aid in tracing, automated settings, consistent temperature, carrying and packaging which will be an alternative to the currently available techniques in practice.