Back Ground: Self-Actualization factors equanimity is the major influencing factor on Job Involvement and Continued Freshness of Appreciation is the next most influencing factor of Job Involvement. The prominence of Self-Actualization in organizational environment especially related to Job Satisfaction, Job Involvement and Organizational Commitment.SelfActualization has strong influence in determining Job Satisfaction, Job Involvement and Organizational Commitment. The purpose of the study to Investigation of Self- Actualization on the Impact of Academic Leaders’ Job Involvement, Organizational Commitment and Job Satisfaction in Tamil Nadu Universities Methods/Statistical Analysis: A cross-sectional design and survey method were utilizedto collect the data and the stratified purposive random sampling method and in SEM model, AMOS 20 used in this study. Findings: Based on the results of the three-mediating model, Job Satisfaction model has mediation effect between Self-Actualization highly significant compared other mediation model Job Involvement and Organizational Commitment. Conclusion: The researcher concluded that Self-Actualization is a vital contribution to job influences Job Satisfaction of Academic Leaders in Tamil Nadu Universities.