Introduction: The goal of treatment of distal fracture of radius is restoration of normal function and prevention of complication like malunion, joint stiffness and deformity but achievement of desired outcome is always a challenge in fracture of distal end of radius. Materials and Methods: Patients with unstable comminuted fracture of distal radius admitted in the department of orthopedics and enrolled for this study based on inclusion and inclusion criteria. For functional assessment of outcome, we used DASH (Disability of the Arm, shoulder and hand) Method. Result: The mean of DASH score was16.24±4.62 in external fixation group and 14.65±3.98 in internal fixation group. Both groups are comparable to each other as it is not statistically significant (P˃ .05). There is no incidence of compressive neuropathy, Sudeck’s osteodystrophy, iatrogenic rupture and nerve injury. Conclusion: DASH score was less in internal fixation group. Post-operative infection was high in internal fixation group. Functional outcome was better in internal fixation group.