Background: The present study was an audit for evaluating the use of blood components in acute systemic infections and its correlation with clinical outcome in children. Materials & methods: A total of 100 subjects were enrolled. Any preterm and term neonates admitted to the NICU and Neonatal Intermediate Care Unit (NIMC) and receiving any transfusion, i.e., fresh frozen plasma (FFP), red cell concentrate (RCC), platelets, and exchange transfusion were included. The data was collected from the medical records. Patients were categorized according to the classification of neonatal conditions by the International Classification of Diseases 11th Revision (ICD-11).