Aim: Evaluate of Shoulder Pain, Depression and Sleep Quality in Hemiplegic Patients Methods: The cross-sectional study which was carried in the Department of Physical Medicine and Rehabilitation, PMCH Patna, Bihar, India, for 1 year. In the scope of the study, patients with hemiplegia who applied to physical therapy and rehabilitation clinic between 2019-2020 evaluated. Patients 18 years of age or older, having a diagnosis of hemiplegia, and agreeing to participate in the study. Patients who did not agree to participate in the study were not included in the study group. The sleep quality of the patients was evaluated with the Pittsburgh Sleep Quality Index (PSQI). Results: The study group consisted of 50 patients, 30 men and 20 women, and the average age of the patients was 69.88 ± 10.84 (20–84) years. The frequency of hemiplegic shoulder pain in the study group was found to be 20% (n=10). The median age of patients with HSP (71.5[55.0- 85.0] years) and patients without HSP (71.0 [20.0-86.0]) were found to be similar (p=0.37). No significant difference was found between hemiplegia duration in patients with and without HSP (3.1[1.0-29.0] weeks vs. (4.6 [1.0-25.0]) (p=0.82). No relationship was found between having shoulder pain in patients with hemiplegia and gender, education level, family support, CT result, antidepressant use, anxiolytic use and antipsychotic use. It was found that the frequency of shoulder pain among patients with hemiplegia did not change according to ambulation status(p=0.088). The median scores of patients with and without shoulder pain on the PSQI (p=0.44) and BDI (p=0.34) scales were found to be similar. Conclusion: No relationship was found between having shoulder pain and age, gender, family support, ambulation status, depression, and sleep quality. It was found that patients with shoulder pain had significantly worse motor functions in patients diagnosed with hemiplegia.