Abstract- Aim: The present study was conducted to quantitatively assess the apical extrusion of debris with three commercially available file systems. Materials & Methods: This study was conducted on forty five freshly extracted maxillary central incisors with non-traumatic methods. All 45 samples were selected carefully and segregated into three study groups based on the three commercially available file systems. Authors have ensured to study only NiTi rotary and filing systems so as to maintain standard and constancy in results. Consequently, in group I Mtwo Basic Sequence Files were used for canal preparation and shaping. In group II, ProFile GT Rotary Files were used in the sequence for accurate canal preparation and shaping. In group III, TF Adaptive Files was used for meticulous canal preparation and shaping. Preweighed glass vials (10 ml) were used for debris collection. Results thus obtained were subjected to statistical analysis. Statistical Analysis & Results: Statistical analysis was attempted using statistical software ‘Statistical Package for the Social Sciences (SPSS)’ version 21. The recorded information was subjected to appropriate statistical tests to obtain p values and mean. P ≤ 0.05 was considered as statistically significant. Debris extrusion in group I was 0.14 milligrams, in group II was 0.23 milligrams and in group III was 0.32 milligrams. The standard deviation for group I, II and II was 0.837, 0.928 and 0.383 respectively. Conclusion: Within the limitations of the study the authors have concluded very significant inferences about the studied file systems. They noticed that maximum amount of root canal debris were extruded when filling was attempted by TF Adaptive Files. However, these inferences must be correlated with other clinical circumstances and operators skills. Authors also propose other studies to be conducted those include larger samples and multi-rooted teeth.