and monocot genus officinalae (Z.officinalae) leaf extract on reactive element species, inhibitor potential changes in arsenic and lead- evoked toxicity in male rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: lead and sodium arsenite together were administered through gastric intubation during 14 consecutive days Group III to Group IX: arsenic and lead induced rats treated with ethanolic extract of Emblica officinalis, Z.officinalae orally for 45 days with different concentrations). At the end of the treatment, control and experimental animals were subjected to oxidative stress markers such as H2O2, *OH, and lipid peroxidation (LPO), antioxidant enzymes of Brain and Testis. Results: arsenic and lead evoked rats showed a major increase within the levels of reactive element species (H2O2, OH* and LPO) with concomitant alterations within the Brain and gonad tissues. Conversely enzymic and non-enzymic inhibitor levels were found to be belittled. However, Associate in Nursing oral effective dose of E.officinalis and Z.officinalae (120 + one hundred twenty mg/kg body weight/ day multiplied the inhibitor enzymes and retrieved the altered levels of ROS and LPO that were evoked by asenic and lead. and monocot genus officinalae (Z.officinalae) leaf extract on reactive element species, inhibitor potential changes in arsenic and lead- evoked toxicity in male rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: lead and sodium arsenite together were administered through gastric intubation during 14 consecutive days Group III to Group IX: arsenic and lead induced rats treated with ethanolic extract of Emblica officinalis, Z.officinalae orally for 45 days with different concentrations). At the end of the treatment, control and experimental animals were subjected to oxidative stress markers such as H2O2, *OH, and lipid peroxidation (LPO), antioxidant enzymes of Brain and Testis. Results: arsenic and lead evoked rats showed a major increase within the levels of reactive element species (H2O2, OH* and LPO) with concomitant alterations within the Brain and gonad tissues. Conversely enzymic and non-enzymic inhibitor levels were found to be belittled. However, Associate in Nursing oral effective dose of E.officinalis and Z.officinalae (120 + one hundred twenty mg/kg body weight/ day multiplied the inhibitor enzymes and retrieved the altered levels of ROS and LPO that were evoked by asenic and lead.