Syphilis is an infectiousdisease introducing stages related with explicit oral lesions. Hence, health care professionals ought to be acquainted with the distinctive syphilis oral signs at each stage and be set up to refer any presumed patient for additional assessment. Though oral signs of syphilis are well on the way to be seen during secondary stage of disease, all phases of the infection can offer ascent to oral lesions. Major oral lesions for example, gumma-related bony destruction and a potential inclination to oral squamous cell carcinoma are related with tertiary disease. Since the occurrence of infective syphilis in heterosexuals has been expanding, there has now been a continuous ascent in the quantity of children brought into the world with congenital syphilis. Thus, the congenital syphilis offers ascend to dental abnormalities as well as bone, skin, and neurological anomalies of the face. This review article portrays the most significant clinical variables of each stage, stressing the oral manifestations.