Aim: To assess and compare age estimation by Drusini’s method and Jeon’s method and correlate chronological age and age estimation by both the methods in Indian Adults. Methodology: Two hundred intraoral periapical radiovisuographs of the patients aged 20–69 years with optimum diagnostic quality radiographic images of permanent mandibular first molars were selected from the digital archive of the Department of Oral Medicine Diagnosis and Radiology from the dental college. Measurements were done using Drusini’s and Jeon’s methods and compared with the chronological age. A P < 0.05 was considered statistically significant. Analysis of variance followed by Tukey’s Post hoc test, t-test.