ABSTRACT: Acute myocardial infarction (AMI) is one of the common diseases in developing countries.(Sathisha et al., 2011)It is generally known as a heart attack, which occurs when there israpid blockage in flow of blood in one or more of Coronary arteries and decreases the supply of blood to heart muscle, leading to necrosis in which enormous death of cells andpermanent damage occur. If blockage is severe, then heart faces cardiac halt. This is very common because ofblockage occur in coronary artery following splitting of atherosclerotic plaque in which uneven collection of lipids,more commonly cholesterol and fatty acid as well as WBC’s specifically macrophagesoccur in walls of artery.AMI is one of an exampleof coronary artery disease, that results into greater than 2.4 million expiries in USA, greater than 4 million expiries in Europe and northern Asia,(Nichols, Townsend, Scarborough, & Rayner, 2014) as well as greater than one third of deaths in advanced countries per year. In this review article, the pathophysiology of acute myocardial infarction along with some uses of drugs is discussed.