Objectives: Coronary heart disease resulting from atherosclerosis of coronary arteries. It is the most common cardiac disease found in autopsies. As number of cases of coronary heart diseases are increasing worldwide and it also a huge challenge in India became challenging in India. The study was designed to assess the histomorphological atherosclerotic changes in coronary arteries based on autopsy and to find out the age and sex related prevalence of atherosclerosis in population of mp of which hearts are received in department of pathology, MGM medical college Indore, India. This study will help in collecting baseline information of prevalence of such lesions which will help in framing health care programs to prevent the formation of these lesions. Methods: In the present study, a total of 200 cases were autopsied to study and grade atherosclerotic lesions in the coronaries. Slides were prepared by sections of these specimens and stained with hematoxylin and eosin for microscopic examination. Results: In the present study, it was observed that 162 cases (81.0%) were males and 38 (19.0%) were females showing atherosclerotic changes. Commonest type of atherosclerosis seen was grade 3. The most frequently involved branch was left anterior descending artery. Relative frequency of lesions increased with age. Conclusions: With high prevalence of cardiovascular disease, the study of clinical atherosclerosis is the need of the day to estimate the disease burden in population. In this study atherosclerotic lesions was observed in very young population which may be an indication that there is need of implementation of anti atherogenic preventive measures in young individuals. It also highlights the importance of cardiovascular risk factors screening from early ages.