Introduction: Enlargement of lymph node may result from the proliferation of lymphocytes intrinsic to lymph nodes, due to an infection or a lymphoproliferative disorder or from the migration and infiltration of nodal tissue by either intrinsic inflammatory cells or metastatic malignant cells. The aim of the present study was to investigate the Accuracy and role of FNAC in diagnosis of etiological profiles of lymphadenopathy and its comparison to histo-pathology examination. Materials and Methods: Lymph node biopsies were received in 72 patients and the biopsy specimens were subjected to FNAC examination after fixing in 10% formalin. Histopathological examination was done and the results were correlated with the cytological reports to evaluate efficacy of the procedure. They were subjected to FNAC and only those thyroid swelling cases admitted to indoor and subsequently underwent surgery were included in this study. After HP study they were compared with preoperative FNAC report.