ransformation to a problem- based learning and early clinical exposure. Evaluation of medical students is always desirable to be uniform and reliable during practical examination. Objective structured practical examination (OSPE) have been tried by few medical universities in Anatomy subject. Aim and objective- The present study is aimed to determine the accuracy, practicality and prospect of Objective Structured Practical Examination as a tool for assessment of teachinglearning outcome in anatomy. Material and Method: Eighty first year MBBS students were evaluated using OSPE during the pre-university examination. 11 OSPE stations was prepared; from which 10 was OSPE stations and 1 was the resting station which was interspaced in-between. Mean marks of student in traditional (TPE) and objective structured practical examination (OSPE) were compared using paired t test. Result: The significant improvement was noted in 58 students. No significant change was observed in performance of 17 students, significant deterioration in performance of 5 students was observed. Conclusion: Use of both OSPE and traditional practical examination should be there for better assessment of the students.