ABSTRACT Introduction: There are limited data available on comparing dexmedetomidine and fentanylas adjuvant to Bupivacaine in brachial plexus block. Considering the low side effect and excellent postoperative analgesic efficacy of two drugs, it is essential to carry out a comparative evaluation of two drugs for their use with bupivacaine as adjuvant in patients undergoing upper limb surgeries which require supraclavicular brachial plexus block. Thus, the present work has been undertaken to study and compare the effect provided by dexmedetomidine and fentanyl as adjuvants to bupivacaine in supraclavicular block. Material and Methods: 90 patients were divided into three groups; Group C (n=30): 0.5% bupivacaine hydrochloride 30ml, Group D (n=30): 0.5% bupivacaine hydrochloride 30ml and 1mcg/kg dexmedetomidine and Group F (n=30): 0.5% bupivacaine hydrochloride 30ml and 1mcg/kg fentanyl. After completion of injection; parameters (HR, RR, SBP, DBP, MAP, SpO2) were noted. Statistical analysis was performed using SPSS version 22.0 IBM. Parametric data was analysed using student ttest. Results: Heart rates were similarly maintained in all the three groups across the time points as revealed by the insignificant p value at all the time points (p>0.05). Mean arterial pressure (MAP) was similarly maintained in all the three groups across the time points as revealed by the insignificant p value at all the time points (p>0.05). One incident of bradycardia was noted in Group F which was managed by giving Inj. Atropine 0.6mg; One patient complained of Dry mouth in Group D; One incidence of nausea was seen in Control group and Group F. Other side effects like hypotension, sedation, or itching were not noted in any of the groups in the present study. Conclusion: The study showed no significant difference in heart rate and mean arterial pressure or any incidence of significant side effects seen with Fentanyl and Dexmeditomidine groups. Thus, we conclude that Dexmedetomidine is better than Fentanyl when added to Bupivacaine or Bupivacaine alone for use in nerve stimulator guided supraclavicular brachial plexus block without any significant complications.