Dakshina Kannada was relatively free from malaria until early 1990 with only sporadic case reports. But since 1990, with a sudden spurt in industrialisation and construction activities, malaria has made a dramatic comeback. There are various studies that show a relationship between blood group and malarial infection. However no studies have been done in the region of Dakshina Kannada In view of the above we conducted a study to determine if any particular blood group confers some degree of protection against severe malarial complication with the objective to determine if any particular blood group confers some degree of protection to severe malarial complication.