Head and neck cancers are the sixth most common type of cancers and has a steady rise in India, predominantly in males .The most common etiological factor contributing for the cancer development is Tobacco consumption in various forms. This was a laboratory based ,retrospective study to assess the prevalence and association of HNSCC in a subset of population of tobacco consumers A total of 50 positive cases of Head and neck squamous cell carcinomas were collected at our hospital for a period of two years and history collected in view of age , sex and tobacco consumption . In this study, 64% affected cases are males and 48% of the cases had the history of tobacco consumption. Tobacco consumption prevails as the sole risk factor for the development of Head and neck squamous cell carcinomas.