Context: Monkey pox is an emerging infectious disease caused by virus transmitted to humans from infected animals mostly rodents. Aim: To assess and improve the knowledge among nursing students particularly about monkey pox its management and prevention. Methods and materials: This is a pre-experimental study conducted at nursing college between July -September 2022.a total of 60 nursing students were enrolled in the study. All the enrolled nursing students were subjected to a detailed questionnaire consisting of various components which includes general information, causes, clinical features and diagnosis, management and its prevention. Results: The mean age of the study group was 51.7, among Nursing students. Most of the nursing students were having lack of proper knowledge regarding monkey pox was seen. The level of knowledge show that 76.7% are having poor knowledge among nursing students, average score was observed is 23.3% among nursing students. The mean difference between pre-test knowledge and post-test knowledge score 8.78. This indicates an increase in knowledge score after undergoing structured teaching programme.to find the significance of gain in knowledge paired in ‘t’ test was computed and the obtained value of ‘t’(59): 19:54 was found to be significant at 0.05 level of significance. Conclusion: monkey pox is a viral zoonotic ailment in children. Studies have continually determined that health professionals with adequate education and training have better knowledge and inclined ness to provide care.