Background:Thyroid dysfunction is common in the general population, especially among older women. The present study was conducted to assess thyroid function in postmenopausal women. Materials & Methods:56 post- menopausal women and equal number of pre- menopausal women were recruited and classified into group I and II respectively. All were subjected to TSH estimation in RIA centre with Immunoradiometric assay kit. T3 and T4 were also estimated if TSH level was abnormal. The sensitivity of TSH estimation was 0.05µIU/ml. Normal level of TSH was taken as 0.5-4.5µIU/ml. Results: There were 2 subjects in group I and 4 in group II with TSH level <0.5 µIU/ml, 50 in group I and 46 in group II had between 0.5-4.5 µIU/ml and 4 in group I and 6 in group II had >4.5 µIU/ml. The prevalence of subclinical hypothyroidism was seen in 2 in group I and 4 in group II and overt hypothyroidism in 1 in group I and 2 in group II. The difference was significant (P< 0.05). The mean TSH level in group I was 3.02 µIU/ml and in group II was 3.86 µIU/ml. The difference was non- significant (P> 0.05). Conclusion: The prevalence of thyroid disorders especially hypothyroidism is more in postmenopausal women than premenopausal women.