Background: To study breast carcinoma based on the expression patterns of ER, PgR, HER2/neu and its Histomorphology. Materials and Methods: The present study is a 4 years study, 1 year retrospective and 3 year prospective study from 1st November 2017 to 31st October 2021, done in the Department of Pathology Kamineni Institute of Medical Sciences, Narketpally. Specimens received with a clinical diagnosis of carcinoma of breast were processed according to standard protocol. The specimen received following neoadjuvant chemotherapy was excluded from the study. Histomorphology of tumor, Nottinghams modification of Scarff Bloom Richardson grading was studied by H&E stained section and the ER, PgR and HER2/neu expression studied by IHC stains.