Introduction: Gallstones are the commonest biliary pathology,the incidence ranging from 10% to 20% of the world population. Over 95% of biliary tract disease is attributable to cholelithiasis. Gallbladder stones are known to produce histopathological changes in the gallbladder. Aim: To study spectrum of gallbladder diseases in cholecystectomy specimens and the incidence of various neoplastic and non neoplastic lesions occurring in gallbladder