Electrophysiological studies revealed that Esmolol causes an increase in sinus cycle length and sinus node recovery time. Electrocardiographic parameters like 'PR' 'QRS' and 'QT' intervals were not prolonged. In contrast to other beta blockers, electrophysiological values return to baseline values within a period of 30 minutes after withdrawing the drug. When infused at a dose of 200 micrograms/kg/minute, Esmolol can significantly reduce the namely, resting heart rate, Systolic blood pressure, rate pressure product, cardiac index. Esmolol can also attenuate isoprenaline induced tachycardia. After obtaining clearance from the Institutional Ethical Committee and informed written consent, a prospective randomized double-blinded study was conducted on sixty patients scheduled for various elective surgical procedures belonging to patients physical status American Society of Anesthesiologists (ASA) Classes I and II were included in the study. In esmolol group the basal heart rate was 97.8bpm. During reversal heart rate increased to 102.7bpm. During drug injection and subsequently heart rate decreased as shown in table. At 15min post extubation heart rate was 84.6bpm which was less than basal.