Background: The occupational hazards of computer use are much more serious and disabling than any other occupation. Health problems in computer users appear to be interrelated and they are musculoskeletal, visual, stress and depression related.1 Methods: A cross sectional study was conducted among all 319 third year computer engineering students and 79 teaching staff in Engineering colleges of lucknow city for 1year from January 2018 to December 2019. The study subjects were interviewed using pre-designed and pretested proforma including Zung Self-Rating Depression Scale. Results: In our study majority (75.37%) of study subjects belonged to 20-22 years age studying B.E Computer science and 274(68.84%) were females and 124(31.15%) were males. Amongst study subjects mild depression were more common who works on computer for 6-9hr for more than 9years 7(1.75%). Conclusion: In our study mild depression is more common in students working on computer for 6-9hr for more than 9years which accumulate over a period of time resulting in severe depression affecting physical and mental health.