Introduction: A progressive decline in liver function lasting longer than six months, including the production of clotting factors and other proteins, the detoxification of hazardous metabolic waste products, and the excretion of bile, is known as chronic liver disease (CLD). The normal range of serum sodium is about 135-145 mEq/L. Its homeostasis is essential for cell function. Abnormal sodium levels can result from an imbalance in the body's overall water balance management. Patients having chronic liver disease often experience the complication of hyponatremia. Although hyponatremia is often described as having sodium level in those patients less than 135 mEq/L, in people with hepatic disease, the threshold is 130 mEq/L. Material and Methods: This is a Prospective Cohort Study was done in the department of General Medicine at Rajshree Medical college, Bareilly Uttar Pradesh. The study population comprised of all patients attending OPD /IPD of medicine department at Rajshree Medical college and Hospital with diagnosis of Chronic Liver Disease fulfilling the inclusion criteria were enrolled for this study. Child Pugh and MELD scores was computed for each patient to determine the severity of cirrhosis. The West Haven criteria was used to make a clinical diagnosis of hepatic encephalopathy. Results: Out of 132 patients, studied most of the patient comes in the 30-50 year age group i.e. 82(62.1%). The mean age of patients was 50.17 ± 10.58, with a range of 30-80 years. Out of 132 patients, 56.8% subjects were do not had hepatic encephalopathy, 15.9% had grade I, 15.2% had grade II, 7.6% subjects had grade III encephalopathy, 4.5% subject had Grade 4. Association between Coagulopathy and serum sodium level, out of 109 study subjects 27 study subjects had serum sodium ≤ 130 meq/L, out of 23 study subjects with coagulopathy 13 study subjects had serum sodium ≤ 130 meq/L, on comparing there is significant difference with p value 0.011.Mean MELD score were significantly higher in patients with less serum concentration. In addition Child Pugh class C was significantly more in patients with serum sodium levels ≤ 130 meq/L as compared to other patients. Hepatic encephalopathy, hepatorenal syndrome, coagulopathy, variceal bleeding were found significantly more common in patients with serum sodium levels less than 130 meq/l.