Background: There are major changes taking place in healthcare for nurses, owing to their role, their education, and the respect they have received, which are contributing to their job security. Working in hospitals usually entails extraordinary psychological and emotional stress in which the nursing staffs have numerous relationships with others, particularly the nursing managers. The increase in work-related stressors and job strain can affect nurses' job security. The aim of this review was to investigate the relationship between job security among nurses and leadership styles at Makkah health cluster in Saudi Arabia, Saudi Arabia 2021 Synthesis Methods: This study employed a quantitative cross-sectional research design. The study was conducted at Makkah health cluster in Saudi Arabia, Saudi Arabia region2021. Design: The systematic review canvassed a convenience sampling of 226 nurses was selected according to inclusion criteria for this study. Tools of data collection: Path-Goal, Leadership Styles Questionnaire, and Job Security Questionnaire tools were used to assess job security levels among nurses working at Makkah health cluster assess the leadership styles among nurses working at Makkah health cluster, and describe the relationship between job security among nurses and leadership styles. Results: The results showed that the majority of participants have a path-goal leadership style as nursing managers. Also, the results of the current study showed that most participants on average had the following job security dimensions and the total job security. The results of the current study showed that there was a significant positive correlation between path-goal leadership styles and job security domains. Conclusion: The study's findings concluded that there has been a significant relationship between job security and leadership style. Hence, the aim of the study was achieved, and the goal was proved that there is a relation between the two variables, so if the manager uses an effective leadership style, this will improve the nurses' job security