Background: Acute poisoning by pesticides is becoming a serious global problem. Knowledge of general pattern of poisoning in a particular region can hopefully lead to early diagnosis and control of poisoning crises, thereby bringing down the morbidity and mortality to minimum. Present study was an attempt to find out some epidemiological factors, pattern and other significant features of poisoning among poisoning cases at a tertiary care hospital. Material and Methods: The present study was a retrospective study conducted in cases of medicolegal autopsy with history of poisoning and in cases that were diagnosed as poisoning after post mortem examination. Results: Of the total 3275 cases of postmortem, poisoning constituted 433 cases amounting to 13.22% during this study period. Majority of cases were from 21-40 yrs (52.66%) followed by 41-60 yrs (27.71%). Majority of cases were males (66.74%) as compared to females (33.26%). Majority were illiterate (62.59%) as compared to literate (36.26%). In present study, majority were married (64.9%), from nuclear family (95.38%), from low socioeconomic class (81.29%). Majority cases survived for less than 1 day period (54.73%) & had manner of death as suicidal (94.46%). In present study, most common poison used were organo-phosphorous compounds (64.43%), aluminum phosphide (5.77%), zinc phosphide (5.77%), corrosive acid poison (5.08%) & carbonates (4.62%). Conclusion: An overall look at the autopsies of the cases of poisoning led to the conclusion that the people were more prone to consume poison in the second to fourth decade of their life & suicide was the dominant manner of death in most of the cases.