Background: Rheumatoid arthritis (RA) is a chronic systemic disease affecting primarily the synovium, leading to joint damage and bone destruction1 RA causes significant morbidity as a result of synovial inflammation, joint destruction and associated disability 2 . Epidemiological studies have shown an increased premature mortality in patients with RA compared with the general population. Several investigators reported an excess of cardiovascular morbidity and mortality among RA patients. Material and methods: This is cross sectional study, total 50 Patients attending Rheumatology outpatient department of General medicine, at Darbhanga medical college and Hospital, Laheriasarai, Darbhanga. Duration period of two years. Conclusion: Patients with Rheumatoid arthritis had significantly reduced levels of serum total cholesterol, LDL-cholesterol, triglyceride, as compared to controls. HDL-cholesterol level was not significantly altered in Rheumatoid arthritis as compared to controls