Human immunodeficiency virus (HIV) infection has persisted as the world’s leading infectious killer. Most of the women infected with HIV are in the reproductive age group and are capable of passing this infection to their babies. Most (90%) of the infections in children aged under 15 years are from maternally-acquired HIV. The benefits of antiretroviral treatment (ART) in decreasing mother to child transmission (MTCT) of HIV infection. Present study is on HIV infection in Pregnancy and its outcomes . This is a Retrospective study done in Tertiary care hospital of RIMS, Adilabad , Telanagana state . 255 HIV positive mothers registered in ART Centre were included in study. 215 were diagnosed in ANC and 40 during PNC. 12 mothers developed tuberculosis. 49 babies were HIV positive, out of which 2 died.15 women died and 216 are alive on ART treatment at present. Timely diagnosis of HIV infection during pregnancy is important for preventing MTCT. HIV infected mothers may give birth to HIV negative babies with the help of multidisciplinary teams. With good antenatal care and multidisciplinary approach HIV-infected women can have good pregnancy outcome.