Introduction:The worldwide pandemic caused by COVID-19highly infectious double mutant variant of SARS-CoV-2 (B.1.617 lineage) attributed to sudden surge of cases in India and was challenged by acute shortage health care personnel and medical equipment required for severe cases treatment like ventilators, ICUs. Isolation is the oldest communicable disease control measure and isolating sources of infection is key measure to break the transmission chain. Advanced medical resources are not required for mild symptomatic patientsbut isolation is needed. The data on the compliance to guidelines and outcome at the end of isolation are scanty in the literature. Material & Methods: A community based cross-sectional study was conducted in asymptomatic and mild symptomatic patient advised home isolation.Information about symptoms, socio-demography, outcome at the end of home isolation and guidelines followed were taken by telephonic interview of 301 patients. Results: Out of 301 home isolated patients 28% completed home isolation without any symptoms, 64% completed with resolved symptoms, 8% required hospital admission during home isolation period. Majority were mild symptomatic 216(71.77%) and 85(28.23%) were asymptomatic. Conclusion:Home isolation for asymptomatic and mild symptomatic patient is useful for both patients and health care system.Majority of patients recovered well in home isolation. But, mass public education about infection prevention and control measure to reduce transmission among household members is needed.