Background: To assess socio-demographic and clinical profile of patients of unipolar and bipolar depression. Materials & methods: 100 patients with confirmed diagnosis of unipolar depression and 100 patients with confirmed diagnosis of bipolar depression were enrolled. Complete demographic details and clinical data of all the patients was obtained. Diagnosis of unipolar and bipolar was confirmed as per the International Statistical Classification of Diseases and Related Health Problem Tenth Revision (ICD-10), were included. A Preformed Performa was made and complete details of all the patients was recorded. Clinical and socio-demographic data of all the subjects was recorded and compared. Assessment of results was done using SPSS software.