Introduction : Previous studies have shown varying results with trans-foraminalapproach epidural steroidinjections performed with particulate versus non-particulate corticosteroids. The purpose of this study was to investigate the difference in pain relief and functional improvement between particulate and non-particulate lumbosacral (MIL) in patients who had undergone both injections through intra-laminar approach. Methods: This was a self-controlled, prospective study of 40 patients who underwent both a methylprednisolone and a dexamethasone intra-laminar injection to the same vertebral level and side. Primary outcomes included pain relief according to the visual analogue scale (VAS) and functional improvement determined by a yes/no answer to questions regarding mobility and the activities of daily living. Post-injection data was recorded at 6, 12, and 24 weeks. Results: A decrease in VAS scores of-3.6 +/- 3, - 3.2 +/- 3.2, -3 +/- 3.1 is noted in methyl prednisolone group as compared to better VAS score projected in patients with dexamethasone group as suggested -3.9+/- 3.2, -3.1 +/- 2.9,- 2.2 +/- 3.2 at 6 weeks, 12 weeks and 24 weeks respectively. Findings positively supports the use of non-particulate steroids for lumbar prolapse intervertebral disc with radicular pain in contrast of safety use of particulate steroids for one of treatment modality in dealing with localized or radicular pain.