Abstract The 2019 pandemic of Corona Virus disease (COVID-19), caused by extreme acute coronaviral syndrome 2 (SARS-CoV-2), exploded in 2020 and produced severe global socio-economic and public health challenges. A subset of patients were also diagnosed with diarrhoea as well as usual characteristics such as fever, toxin and dyspnea. However, there has been inadequate attention to the clinical characteristics and prognoses of COVID-19- associated diarrhoea1–3 . The analysis discusses the occurrence, pathogenesis, clinical characteristics, improvements in faecal viruses, forecasts and influences influential to diarrhoea associated with COVID-19. In patients with COVID-19, the occurrence of diarrhoea was registered between 2% and 49.5%. SARS-CoV-2 of ACE-2 expressing the small intestine epithelial cells, which causes local intestinal damages, was reported as the key cause of diarrhoea. This cell invasion may be a main factor in pharyngeal swab positive for the long duration of SARS-CoV-2 found in faeces. The related diarrhoea in these patients disrupts the bowel flora equilibrium and leads to a greater severity of diseases and a better forecast. Patients with positive fecal-nucleic acid testing and intestinal microflower diseases should be careful with COVID-19 induced diarrhoea, and design more appropriate prevention and care options for these patients.