Siddha system of medicine is well known for its contributions towards skin diseases through its ancient texts. Veppampattai thylam is one among the external medication which has been indicated for the treatment of chronic skin conditions like eczema, dermatitis, psoriasis, scabies etc. It is a herbal formulation containing Melia azadirachta bark (Veppampattai), Hemidesmus indicus root (Nannari ver), Rubia cordifolia root (Manjitti ver), Eletaria cardomom seeds (Elarisi). This herbal oil is being prescribed by Siddha physicians as it reduces the itching, burning sensations, skin lesions and inflammations that are common symptoms of the skin diseases. This paper deals with the scientific analysis on the pharmacological properties of these ingredients towards the treatment of chronic Skin diseases.