Abstract This is a short review on the formation of crack patterns focusing on two artificial claysystems:Bentonite and Laponite and also some biological fluids under various physical conditions. For last few decades the study of crack patterns attracted researchers of various fields for its diverse applications in a typical fields, like geophysical systems, biophysics and so on. Practically, the study of desiccation cracks can be useful either to prevent crack formation or to make use of them. We have also tried to focus on physical conditions of formation of cracks, such as layer thickness, temperature, drying rate, the property of the substrate, solvent property etc.