ABSTRACT Nanotechnology has laid the foundation to nanomedicine production and still appears the cornerstone for ongoing global medical studies, since at nanometric scale the physical properties of materials vary, resulting in innovative magnetic, biochemical, visual and electrical characteristics. In addition to the huge amount of funds and capital, the emergence of new medicinal products against the changed pathological condition of our bodies is also challenging in view of maximum rate of failure. The modifications with in structures of products in nano particle form, altered the way of diagnosis and treatment of destructive human diseases by using medicines capable in effective management by modifying the step of discharge, delivery and disposal in the body. Smart nanoparticles are such one of the most demanding nano systems for drug delivery to targeted genes that can overcome the problems during treatment itself. Present review paper discussed the types and uses of various types of response-based smart nanoparticles to drug delivery practices.