In modern era, the use of plastic product in different sector of industry is increasing day by day.Plastic waste management and recycling became a serious global issue as it affects living beings from all the ecosystems.Their disperse disposal in land andwater arouses threats for human, wildlife and aqua life. Researches have been carried out on plastic degradation to find solutionto overcome these environmental hazards. Biodegradation emerges as one of the promising solution to manage theplastic waste which could not be recycled. In biodegradation processmicroorganism and their enzymes are applied to degrade the syntheticand bio-based plastics. This review gives the current progresson biodegradation of various plastic polymers by microorganisms andenzymes to determine the extent of degradation.