Aim: The aim of this study was to analysis of mesh related infections in a tertiary care centre. Methods: A retrospective descriptive study was conducted in the department of Surgery for one year and 50 patients were included in the study. Results: Mesh infection was more common in males. Among 50 patients, 40 were males and 10 female patients. Majority of the patients were in the age group 40-50 (40%) followed by 50-60 age group 30%. 30% cases were repaired with open repair and rest of the patients was repaired with lap repair. In our study, mesh infection was more common in obese patients with a mean BMI of 32.70+/-1.78kg/m2. (Range 30.40-34.10). 40% patients had comorbidities. The antibiotic protocol was followed in 48 cases out of 50. Antibiotic has used according to the protocol of our hospital; it was followed in 48 patients in the first surgery i.e., hernia repair surgery. Parenteral cephalosporin was used in 48 patients and amoxicillinclavulanic acid in 2 patients. Antibiotic has repeated if the procedure was beyond 2 hours. After postoperative day 2, patients were switched over to oral antibiotics for three days. Likewise, during the second admission, i.e., when the patient was admitted with mesh infection, 48 patients were given cephalosporin and 2 patients were given Piperacillin tazobactam. Conclusion: In our study incidence was more common after laparoscopic surgeries because there was a lapse in the sterilization process of the laparoscopic instruments, which was rectified with timely culture sensitivity tests and stringent sterilization process.