In this present investigation piperine loaded nanogel for skin cancer was formulated by using piperine, carbopol, sodium tripolyphosphate Method Piperine loaded Nanogel is formulated by Ion gelation method using stpp, chitosan and it is evaluated by Entrapment efficiency, particle size analyzer, zeta potential, effect of particle size, Fourier- transformed infrared spectroscopy, screening electron microscopy, ex Vivo permeation study, box behnken design, regression analysis, formulation of nanoparticles, incorporation into transdermal nanogel and evaluated by physical examination drug content, extrudability, spreadibility, in Vivo study, washablity, stability study of gel, in Vivo dissolution, drug diffusion study