With an incidence of just 2-4%, wrist TB is a rather uncommon condition. The radiocarpal joint and the inter-carpal joint involvement are particularly rare. Due to the slow progression of symptoms, it is often detected when there has been significant carpal destruction or arthritis. The condition occurred in a 55-year-old female, presenting with wrist pain for 2 years. Clinical examination revealed a localized ganglion-like swelling over the left wrist with a full range of motion but painful terminally. Following radiographic examination, the diagnosis of osteoarticular tuberculosis was suspected, and was confirmed on histopathological analysis. Patient underwent debridement with synovectomy followed by anti-bacillary chemotherapy of 12 months which promoted healing and good outcome. We conclude from this case that tuberculous arthritis is uncommon and the functional outcome depends on obtaining an early diagnosis before radiological signs of joint damage appear.